Merle phenotypes in dogs – SILV SINE insertions from Mc to Mh
نویسندگان
چکیده
منابع مشابه
Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog.
Merle is a pattern of coloring observed in the coat of the domestic dog and is characterized by patches of diluted pigment. This trait is inherited in an autosomal, incompletely dominant fashion. Dogs heterozygous or homozygous for the merle locus exhibit a wide range of auditory and ophthalmologic abnormalities, which are similar to those observed for the human auditory-pigmentation disorder W...
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A homozygous merle Australian shepherd bitch produced two nonmerle offspring and 64 that carried the merle allele. The two nonmerle offspring produced no merles when bred to nonmerles, indicating that the germinal reversion to nonmerle was stable. This occurrence is further evidence that the merle allele is due to a transposable DNA element.
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Short interspersed repetitive elements, or SINEs, are tRNA-derived retroposons that are dispersed throughout eukaryotic genomes and can be present in well over 10(4) total copies. The enormous volume of SINE amplifications per organism makes them important evolutionary agents for shaping the diversity of genomes, and the irreversible, independent nature of their insertion allows them to be used...
متن کاملA SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs.
Agouti Signaling Protein (ASIP) controls the localized expression of red and black pigment in the domestic dog through interaction with other genes, such as Melanocortin 1 Receptor and Beta-Defensin 103. Specific ASIP alleles are necessary for many of the coat color patterns, such as black-and-tan and saddle tan. Mutations in 2 ASIP alleles, a(y) and a, have previously been identified. Here, we...
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W ith 400 recognized breeds worldwide and a recently completed draft genomic sequence, the dog has emerged as a model organism of choice for the genetic dissection of morphological traits and diseases (1–3). Of great interest is the fact that a number of disorders in purebred dogs are also of human medical relevance (1, 2). In this context, the study by Clark et al. (4) in this issue of PNAS is...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0198536